Toward a realistic model of mutations affecting fitness.

نویسندگان

  • Peter D Keightley
  • Michael Lynch
چکیده

Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Mapping the Fitness Landscape of Gene Expression Uncovers the Cause of Antagonism and Sign Epistasis between Adaptive Mutations

How do adapting populations navigate the tensions between the costs of gene expression and the benefits of gene products to optimize the levels of many genes at once? Here we combined independently-arising beneficial mutations that altered enzyme levels in the central metabolism of Methylobacterium extorquens to uncover the fitness landscape defined by gene expression levels. We found strong an...

متن کامل

The effect of induced mutations on quantitative traits in Arabidopsis thaliana: Natural versus artificial conditions

Mutations are the ultimate source of all genetic variations. New mutations are expected to affect quantitative traits differently depending on the extent to which traits contribute to fitness and the environment in which they are tested. The dogma is that the preponderance of mutations affecting fitness will be skewed toward deleterious while their effects on nonfitness traits will be bidirecti...

متن کامل

Mutational interference and the progression of Muller's ratchet when mutations have a broad range of deleterious effects.

Deleterious mutations can accumulate in asexual haploid genomes through the process known as Muller's ratchet. This process has been described in the literature mostly for the case where all mutations are assumed to have the same effect on fitness. In the more realistic situation, deleterious mutations will affect fitness with a wide range of effects, from almost neutral to lethal. To elucidate...

متن کامل

The effect of antagonistic pleiotropy on the estimation of the average coefficient of dominance of deleterious mutations.

We investigate the impact of antagonistic pleiotropy on the most widely used methods of estimation of the average coefficient of dominance of deleterious mutations from segregating populations. A proportion of the deleterious mutations affecting a given studied fitness component are assumed to have an advantageous effect on another one, generating overdominance on global fitness. Using diffusio...

متن کامل

Title of Document : MOVING TOWARD AN OPTIMUM : THE ADAPTATION GENETICS OF ARABIDOPSIS THALIANA

Title of Document: MOVING TOWARD AN OPTIMUM: THE ADAPTATION GENETICS OF ARABIDOPSIS THALIANA. Frank Warren Stearns Jr., Doctor of Philosophy, 2015 Directed By: Professor Charles B. Fenster, Department of Biology Adaptation accounts for many of the interesting characteristics of biodiversity. Despite this, the genetic mechanisms underlying the process of adaptation in nature are largely unknown....

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Evolution; international journal of organic evolution

دوره 57 3  شماره 

صفحات  -

تاریخ انتشار 2003